Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics

The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection. While proteolytic cleavage of GP by endosomal cathepsins and binding of the cellular receptor Niemann-Pick C1 protein (NPC1) are essential step...

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Autori principali:	Natasha D. Durham, Angela R. Howard, Ramesh Govindan, Fernando Senjobe, J. Maximilian Fels, William E. Diehl, Jeremy Luban, Kartik Chandran, James B. Munro
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2020-01-01
Serie:	Viruses
Soggetti:	ebola virus envelope glycoprotein conformational dynamics single-molecule fret virus entry
Accesso online:	https://www.mdpi.com/1999-4915/12/1/103
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