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Genome-Wide Screening in Human Embryonic Stem Cells Highlights the Hippo Signaling Pathway as Granting Synthetic Viability in ATM Deficiency

<i>ATM</i> depletion is associated with the multisystemic neurodegenerative syndrome ataxia–telangiectasia (A–T). The exact linkage between neurodegeneration and <i>ATM</i> deficiency has not been established yet, and no treatment is currently available. In this study, we aimed to identify synthetic...

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Principais autores: Ruth Viner-Breuer, Tamar Golan-Lev, Nissim Benvenisty, Michal Goldberg
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-05-01
Serier:Cells
Fag:
<i>ATM</i>
Hippo signaling pathway
ataxia–telangiectasia
DNA damage
neurodegeneration
human embryonic stem cells
Online adgang:https://www.mdpi.com/2073-4409/12/11/1503
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