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A Cationic Tetraphenylethene as a Light-Up Supramolecular Probe for DNA G-Quadruplexes

Guanine-quadruplexes (G4s) are targets for anticancer therapeutics. In this context, human telomeric DNA (HT-DNA) that can fold into G4s sequences are of particular interest, and their stabilization with small molecules through a visualizable process has become a challenge. As a new type of ligand f...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Clément Kotras, Mathieu Fossépré, Maxime Roger, Virginie Gervais, Sébastien Richeter, Philippe Gerbier, Sébastien Ulrich, Mathieu Surin, Sébastien Clément
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-07-01
Schriftenreihe:Frontiers in Chemistry
Schlagworte:
tetraphenylethene
G-quadruplexes
fluorescence
light-up probe
supramolecular
Online-Zugang:https://www.frontiersin.org/article/10.3389/fchem.2019.00493/full
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