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Potential application of sucrose acetate isobutyrate, and glyceryl monooleate for nanonization and bioavailability enhancement of rivaroxaban tablets

This study aimed to investigate the use of Sucrose acetate isobutyrate (SAIB) and Glyceryl monooleate (GMO) as co-formers for creating Cubosomes and SAIB-based nanodispersions of Rivaroxaban (RXB). The process utilized a modified melt dispersion technique with varying polymer: drug ratios (0.5:1, 0....

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Principais autores: Adam A. Al-Shoubki, Mahmoud H. Teaima, Rehab Abdelmonem, Mohamed A. El-Nabarawi, Sammar Fathy Elhabal
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-12-01
Serier:Pharmaceutical Science Advances
Fag:
Nanonization
Rivaroxaban
Sucrose acetate isobutyrate
Glyceryl monooleate
Bioavailability enhancement
Online adgang:http://www.sciencedirect.com/science/article/pii/S2773216923000132
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