Activation of hypoactive parvalbumin-positive fast-spiking interneurons restores dentate inhibition to reduce electrographic seizures in the mouse intrahippocampal kainate model of temporal lobe epilepsy

Parvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits. Most dentate PV+ interneurons survive status epilepticus, but surviving PV+ i...

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Autori principali:	Sang-Hun Lee, Young-Jin Kang, Bret N. Smith
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-12-01
Serie:	Neurobiology of Disease
Soggetti:	Temporal lobe epilepsy GABAergic interneuron Parvalbumin-expressing basket cell Dentate gyrus
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0969996124003395
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