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Synthesis and Antiproliferative Activity of Novel Dehydroabietic Acid-Chalcone Hybrids

Dehydroabietic Acid (DHA, <b>1</b>) derivatives are known for their antiproliferative properties, among others. In the context of this work, DHA was initially modified to two key intermediates bearing a C18 methyl ester, a phenol moiety at C12, and an acetyl or formyl group at C13 position. These de...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sophia Grigoropoulou, Dimitra Manou, Antonia I. Antoniou, Artemis Tsirogianni, Carlo Siciliano, Achilleas D. Theocharis, Constantinos M. Athanassopoulos
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-06-01
Schriftenreihe:Molecules
Schlagworte:
dehydroabietic acid
chalcones
hybrids
natural products
breast cancer
5-FU
Online-Zugang:https://www.mdpi.com/1420-3049/27/11/3623
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