Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease

Abstract Mitapivat is an investigational, oral, small‐molecule allosteric activator of pyruvate kinase (PK). PK is a regulatory glycolytic enzyme that is key in providing the red blood cell (RBC) with sufficient amounts of adenosine triphosphate (ATP). In sickle cell disease (SCD), decreased 2,3‐DPG...

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Hlavní autoři:	Myrthe J. vanDijk, Titine J. J. Ruiter, Sigrid van derVeen, Minke A. E. Rab, Brigitte A. vanOirschot, Jennifer Bos, Cleo Derichs, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Roger E. G. Schutgens, Wouter W. vanSolinge, Judith J. M. Jans, Eduard J. vanBeers, Richard vanWijk
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2024-06-01
Edice:	HemaSphere
On-line přístup:	https://doi.org/10.1002/hem3.109
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