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HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer

Abstract Background B7 homolog 1 (B7-H1) overexpression on tumor cells is an important mechanism of immune evasion in gastric cancer (GC). Elucidation of the regulation of B7-H1 expression is urgently required to guide B7-H1-targeted cancer therapy. Interferon gamma (IFN-γ) is thought to be the main...

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Principais autores: Rui Deng, Peng Zhang, Weizhen Liu, Xiangyu Zeng, Xianxiong Ma, Liang Shi, Tao Wang, Yuping Yin, Weilong Chang, Pei Zhang, Guobin Wang, Kaixiong Tao
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-12-01
Colecção:Clinical Epigenetics
Assuntos:
Gastric cancer
Immune evasion
B7-H1
HDAC
IFN-γ
Acesso em linha:http://link.springer.com/article/10.1186/s13148-018-0589-6
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