Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment

Abstract Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated analysis of spatial and single-cell transcriptomics data across six common cancer types, we identified four distinc...

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Autores principales:	Chenxi Ma, Chengzhe Yang, Ai Peng, Tianyong Sun, Xiaoli Ji, Jun Mi, Li Wei, Song Shen, Qiang Feng
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2023-10-01
Colección:	Molecular Cancer
Materias:	Spatial transcriptomics Single-cell RNA sequencing Pan-cancer analysis Cancer-associated fibroblasts Tumor microenvironment Tumor immunotherapy
Acceso en línea:	https://doi.org/10.1186/s12943-023-01876-x
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