Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is a nasty disease with extremely high malignancy and poor prognosis. Annexin A3 (ANXA3) is a potential prognosis biomarker, displaying an excellent correlation of ANXA3 overexpression with patients' poor prognosis. Silencing the expression of ANXA3 effectively i...

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Váldodahkkit:	Yongxi Liang, Delin Min, Hulin Fan, Kunlin Liu, Juchuanli Tu, Xueyan He, Bingjie Liu, Lu Zhou, Suling Liu, Xun Sun
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2023-04-01
Ráidu:	Acta Pharmaceutica Sinica B
Fáttát:	Annexin A3 (ANXA3) Degrader Triple-negative breast cancer Ubiquitination Patient-derived xenograft
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2211383522004907
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