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Transcript errors generate amyloid-like proteins in human cells

Abstract Aging is characterized by the accumulation of proteins that display amyloid-like behavior. However, the molecular mechanisms by which these proteins arise remain unclear. Here, we demonstrate that amyloid-like proteins are produced in a variety of human cell types, including stem cells, bra...

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Principais autores: Claire S. Chung, Yi Kou, Sarah J. Shemtov, Bert M. Verheijen, Ilse Flores, Kayla Love, Ashley Del Dosso, Max A. Thorwald, Yuchen Liu, Daniel Hicks, Yingwo Sun, Renaldo G. Toney, Lucy Carrillo, Megan M. Nguyen, Huang Biao, Yuxin Jin, Ashley Michelle Jauregui, Juan Diaz Quiroz, Elizabeth Head, Darcie L. Moore, Stephen Simpson, Kelley W. Thomas, Marcelo P. Coba, Zhongwei Li, Bérénice A. Benayoun, Joshua J. C. Rosenthal, Scott R. Kennedy, Giorgia Quadrato, Jean-Francois Gout, Lin Chen, Marc Vermulst
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2024-10-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-024-52886-2
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