Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease

Abstract Current therapies for inflammatory bowel disease (IBD) often fail to achieve complete remission and are associated with systemic toxicity owing to their broad immunosuppressive effects. To overcome these limitations, we developed a bioengineered extracellular vesicle (EV) platform that modu...

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Autori principali:	Mi-Kyung Oh, Hyun Sung Park, Dong-Hoon Chae, Aaron Yu, Jae Han Park, Jiyoung Heo, Keonwoo Cho, Jiho Kim, Byeonghwi Lim, Jun-Mo Kim, Jordan E. Axelrad, Kyung Ku Jang, Jong Pil Im, Seong-Joon Koh, Byung-Soo Kim, Kyung-Rok Yu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2025-12-01
Serie:	Signal Transduction and Targeted Therapy
Accesso online:	https://doi.org/10.1038/s41392-025-02516-0
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