GM1 ganglioside exerts protective effects against glutamate‐excitotoxicity via its oligosaccharide in wild‐type and amyotrophic lateral sclerosis motor neurons

Alterations in glycosphingolipid metabolism have been linked to the pathophysiological mechanisms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons. Accordingly, administration of GM1, a sialic acid‐containing glycosphingolipid, is protective against neurona...

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Ngā kaituhi matua:	Giulia Lunghi, Erika Di Biase, Emma Veronica Carsana, Alexandre Henriques, Noelle Callizot, Laura Mauri, Maria Grazia Ciampa, Luigi Mari, Nicoletta Loberto, Massimo Aureli, Sandro Sonnino, Michael Spedding, Elena Chiricozzi, Maria Fazzari
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2023-12-01
Rangatū:	FEBS Open Bio
Ngā marau:	amyotrophic lateral sclerosis excitotoxicity GM1 ganglioside GM1 oligosaccharide intracellular aggregates mitochondria
Urunga tuihono:	https://doi.org/10.1002/2211-5463.13727
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!