Pharmacokinetics, Pharmacodynamics and Bioavailability of ACM‐001.1 (S‐Pindolol Benzoate) in Healthy Volunteers

ABSTRACT Background S‐pindolol has metabolic effects of potential benefit in cancer cachexia: reduced catabolism through nonselective β‐blockade; increased anabolism through partial β2 receptor agonism; and increased appetite and reduced fatigue through central 5‐hydroxytryptamine/serotonin receptor...

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Hauptverfasser:	Frank Misselwitz, Dennis Henderson, Somasekhara R. Menakuru, Elaine Morten, Chris Roe, Gareth Whitaker, Stefan Wohlfeil, John McDermott
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2025-02-01
Schriftenreihe:	Journal of Cachexia, Sarcopenia and Muscle
Schlagworte:	ACM‐001.1 bioequivalence cancer cachexia pharmacodynamics pharmacokinetics stereoconversion
Online-Zugang:	https://doi.org/10.1002/jcsm.13651
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