Molecular underpinnings and environmental drivers of loss of heterozygosity in Drosophila intestinal stem cells

Summary: During development and aging, genome mutation leading to loss of heterozygosity (LOH) can uncover recessive phenotypes within tissue compartments. This phenomenon occurs in normal human tissues and is prevalent in pathological genetic conditions and cancers. While studies in yeast have defi...

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Principais autores:	Lara Al Zouabi, Marine Stefanutti, Spyridon Roumeliotis, Gwenn Le Meur, Benjamin Boumard, Nick Riddiford, Natalia Rubanova, Mylène Bohec, Louis Gervais, Nicolas Servant, Allison J. Bardin
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2023-12-01
Series:	Cell Reports
Assuntos:	CP: Developmental biology CP: Genomics
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124723014973
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