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Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment

Management of gastrointestinal stromal tumors (GISTs) has been revolutionized by the identification of activating mutations in KIT and PDGFRA and clinical application of RTK inhibitors in advanced disease. Stratification of GISTs into molecularly defined subsets provides insight into clinical behavi...

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Principais autores: Shuai Ye, Dinara Sharipova, Marya Kozinova, Lilli Klug, Jimson D’Souza, Martin G. Belinsky, Katherine J. Johnson, Margret B. Einarson, Karthik Devarajan, Yan Zhou, Samuel Litwin, Michael C. Heinrich, Ronald DeMatteo, Margaret von Mehren, James S. Duncan, Lori Rink
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2021-01-01
Serier:JCI Insight
Fag:
Oncology
Therapeutics
Online adgang:https://doi.org/10.1172/jci.insight.143474
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