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Effects of hypothermic oxygenated machine perfusion on bile composition after liver transplantation – Findings from a randomized controlled trial

Background & Aims: In liver transplantation, bile acid (BA) toxicity contributes to injury of both hepatocytes and cholangiocytes. While hypothermic oxygenated machine perfusion (HOPE) reduces ischemia–reperfusion injury (IRI) and improves clinical outcomes, its impact on bile composition remain...

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Sábháilte in:
Príomhchruthaitheoirí: Frederik Schliephake, Isabella Lurje, Deniz Uluk, Janina Eden, Zoltan Czigany, Justus Pein, Peri Husen, Cornelius Engelmann, Christoph Michalski, Marlene Kohlhepp, Pavel Strnad, Philipp Dutkowski, Frank Tacke, Ulf Peter Neumann, David Meierhofer, Georg Lurje
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2026-02-01
Sraith:JHEP Reports
Ábhair:
Hypothermic oxygenated machine perfusion (HOPE)
Bile transporters
Biliary phospholipids
Bile acid composition
Liver transplantation (LT)
Ischemia–reperfusion injury (IRI)
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2589555925003295
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