Non-invasive MRI of blood-cerebrospinal fluid-barrier function in a mouse model of Alzheimer’s disease: a potential biomarker of early pathology

Abstract Background Choroid plexus (CP) or blood-cerebrospinal fluid-barrier (BCSFB) is a unique functional tissue which lines the brain’s fluid-filled ventricles, with a crucial role in CSF production and clearance. BCSFB dysfunction is thought to contribute to toxic protein build-up in neurodegene...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Charith Perera, Renata Cruz, Noam Shemesh, Tânia Carvalho, David L. Thomas, Jack Wells, Andrada Ianuș
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-12-01
Schriftenreihe:	Fluids and Barriers of the CNS
Schlagworte:	Alzheimer’s disease Choroid plexus Blood CSF barrier Brain perfusion Arterial spin labelling MRI 3xTg mouse model
Online-Zugang:	https://doi.org/10.1186/s12987-024-00597-7
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