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A systematic evaluation of state-of-the-art deconvolution methods in spatial transcriptomics: insights from cardiovascular disease and chronic kidney disease

A major challenge in sequencing-based spatial transcriptomics (ST) is resolution limitations. Tissue sections are divided into hundreds of thousands of spots, where each spot invariably contains a mixture of cell types. Methods have been developed to deconvolute the mixed transcriptional signal into...

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Autori principali: Alban Obel Slabowska, Charles Pyke, Henning Hvid, Leon Eyrich Jessen, Simon Baumgart, Vivek Das
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-03-01
Serie:Frontiers in Bioinformatics
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Accesso online:https://www.frontiersin.org/articles/10.3389/fbinf.2024.1352594/full
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