Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.

Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report tha...

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Auteurs principaux:	Lisa Marcinowski, Mélanie Tanguy, Astrid Krmpotic, Bernd Rädle, Vanda J Lisnić, Lee Tuddenham, Béatrice Chane-Woon-Ming, Zsolt Ruzsics, Florian Erhard, Corinna Benkartek, Marina Babic, Ralf Zimmer, Joanne Trgovcich, Ulrich H Koszinowski, Stipan Jonjic, Sébastien Pfeffer, Lars Dölken
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2012-02-01
Collection:	PLoS Pathogens
Accès en ligne:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002510&type=printable
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