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Effects of <i>p</i>-Cresol on Oxidative Stress, Glutathione Depletion, and Necrosis in HepaRG Cells: Comparisons to Other Uremic Toxins and the Role of <i>p</i>-Cresol Glucuronide Formation

The toxicological effects of <i>p</i>-cresol have primarily been attributed to its metabolism products; however, very little human data are available in the key organ (i.e., liver) responsible for the generation of these metabolites. Experiments were conducted in HepaRG cells utilizing the following...

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Detalhes bibliográficos
Principais autores: Sang Zhu, Yan Rong, Tony K. L. Kiang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-06-01
coleção:Pharmaceutics
Assuntos:
Acesso em linha:https://www.mdpi.com/1999-4923/13/6/857
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