The nonantibiotic small molecule cyslabdan enhances the potency of β-lactams against MRSA by inhibiting pentaglycine interpeptide bridge synthesis.

The nonantibiotic small molecule cyslabdan, a labdan-type diterpene produced by Streptomyces sp. K04-0144, markedly potentiated the activity of the β-lactam drug imipenem against methicillin-resistant Staphylococcus aureus (MRSA). To study the mechanism of action of cyslabdan, the proteins that bind...

Olles dieđut

Bibliográfalaš dieđut

Váldodahkkit:	Nobuhiro Koyama, Yuriko Tokura, Daniela Münch, Hans-Georg Sahl, Tanja Schneider, Yoshio Shibagaki, Haruo Ikeda, Hiroshi Tomoda
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Public Library of Science (PLoS) 2012-01-01
Ráidu:	PLoS ONE
Liŋkkat:	http://europepmc.org/articles/PMC3490914?pdf=render
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!