Prospective Tracking of Donor-Reactive T-Cell Clones in the Circulation and Rejecting Human Kidney Allografts

BackgroundAntigen recognition of allo-peptides and HLA molecules leads to the activation of donor-reactive T-cells following transplantation, potentially causing T-cell-mediated rejection (TCMR). Sequencing of the T-cell receptor (TCR) repertoire can be used to track the donor-reactive repertoire in...

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Detalles Bibliográficos

Principais autores:	Constantin Aschauer, Kira Jelencsics, Karin Hu, Andreas Heinzel, Mariella Gloria Gregorich, Julia Vetter, Susanne Schaller, Stephan M. Winkler, Johannes Weinberger, Lisabeth Pimenov, Guido A. Gualdoni, Michael Eder, Alexander Kainz, Anna Regina Troescher, Heinz Regele, Roman Reindl-Schwaighofer, Thomas Wekerle, Johannes Bernhard Huppa, Megan Sykes, Rainer Oberbauer
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2021-10-01
Series:	Frontiers in Immunology
Assuntos:	T-cell receptor alloreactivity kidney transplant rejection next generation sequencing network analysis
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.750005/full
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