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Heart Rate and Extracellular Sodium and Potassium Modulation of Gap Junction Mediated Conduction in Guinea Pigs

Background: Recent studies suggested that cardiac conduction in murine hearts with narrow perinexi and 50% reduced connexin43 (Cx43) expression is more sensitive to relatively physiological changes of extracellular potassium ([K+]o) and sodium ([Na+]o). Purpose: Determine whether similar [K+]o and [...

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Main Authors: Michael eEntz, Sharon A George, Michael J Zeitz, Tristan eRaisch, James W Smyth, Steven ePoelzing
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Physiology
Subjects:
Electrophysiology
Potassium
Sodium
gap junction
cardiac conduction
Ephaptic coupling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00016/full
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