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CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to skin in lichen planus

Lichen planus (LP) is a chronic, debilitating, inflammatory disease of the skin and mucous membranes that affects 1%–2% of Americans. Its molecular pathogenesis remains poorly understood, and there are no FDA-approved treatments. We performed single-cell RNA sequencing on paired blood and skin sampl...

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Hlavní autoři: Anna E. Kersh, Satish Sati, Jianhe Huang, Christina Murphy, Olivia Ahart, Thomas H. Leung
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical investigation 2024-10-01
Edice:JCI Insight
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On-line přístup:https://doi.org/10.1172/jci.insight.179899
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