Reprogramming the immunosuppressive breast cancer microenvironment: integrating cellular, metabolic, and stromal targets for rational immunotherapy

Breast cancer, a highly heterogeneous malignancy and a leading cause of cancer-related mortality among women worldwide, is profoundly shaped in its initiation, progression, and therapeutic response by the tumor immune microenvironment (TIME). This review consolidates recent advances in deciphering t...

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Autors principals:	Chang Ma, Hoon Koon Teoh, Yang Zhao, Yifan Wang, Jun Zhao, Yan Liu, Chen Zhao, Hooi Tin Ong
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-02-01
Col·lecció:	Frontiers in Immunology
Matèries:	breast cancer immune evasion immunotherapy macrophage plasticity metabolic reprogramming tumor microenvironment
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1760782/full
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