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Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

Human Epidermal growth factor Receptor 4 (HER4 or ERBB4) carries out essential functions in the development and maintenance of the cardiovascular and nervous systems. HER4 activation is regulated by a diverse group of extracellular ligands including the neuregulin (NRG) family and betacellulin (BTC)...

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Autori principali: Raphael Trenker, Devan Diwanji, Tanner Bingham, Kliment A Verba, Natalia Jura
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2024-03-01
Serie:eLife
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Accesso online:https://elifesciences.org/articles/92873
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