Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe)

Myeloid-derived suppressor cells (MDSCs) are known to play a critical role in the suppression of T cell antitumor responses. Our preclinical data showed that the phosphodiesterase (PDE)-5 inhibitor sildenafil impaired MDSC functions, enhanced intratumoral T cell activity and prolonged survival of me...

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Hlavní autoři:	Jessica C. Hassel, Huanhuan Jiang, Carolin Bender, Julia Winkler, Alexandra Sevko, Ivan Shevchenko, Niels Halama, Antonia Dimitrakopoulou-Strauss, Walter E. Haefeli, Dirk Jäger, Alexander Enk, Jochen Utikal, Viktor Umansky
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2017-09-01
Edice:	OncoImmunology
Témata:	immunotherapy melanoma myeloid suppressor cells phosphodiesterase-5 inhibitor tadalafil
On-line přístup:	http://dx.doi.org/10.1080/2162402X.2017.1326440
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