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Validation and clinical application of a method to quantify efavirenz in cervicovaginal secretions from flocked swabs using liquid chromatography tandem mass spectrometry [version 3; peer review: 2 approved]

Background : A liquid chromatography tandem mass spectrometry method to quantify drugs in dried cervicovaginal secretions from flocked swabs was developed and validated using the antiretroviral efavirenz as an example. Methods: Cervicovaginal swabs (CVS) were prepared by submerging flocked swabs in...

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Principais autores: Adeniyi Olagunju, Andrew Owen, Oluwasegun Eniayewu, Jacinta Nwogu, Alieu Amara, Shakir Atoyebi, Ebunoluwa Adejuyigbe, Oluseye Bolaji, John Kpamor, Saye Khoo
Format: Artigo
Sprog:Inglês
Udgivet: Wellcome 2022-07-01
Serier:Wellcome Open Research
Fag:
LC-MS/MS
Cervicovaginal fluid
Swab
Pharmacokinetics
Efavirenz
eng
Online adgang:https://wellcomeopenresearch.org/articles/6-246/v3
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