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General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases

The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review,...

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Détails bibliographiques
Auteurs principaux: Ozlem Altintas, Michael R. MacArthur
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2024-09-01
Collection:Frontiers in Aging
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Accès en ligne:https://www.frontiersin.org/articles/10.3389/fragi.2024.1447370/full
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