Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration
About 40 years ago the lipidization of hydrophilic drugs was proposed to induce their brain targeting by transforming them into lipophilic prodrugs. Unfortunately, lipidization often transforms a hydrophilic neuroactive agent into an active efflux transporter (AET) substrate, with consequent rejecti...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2021-07-01
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| coleção: | Pharmaceutics |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/1999-4923/13/8/1144 |
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