Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes

Abstract Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome characterized by progressive loss of fat and lean mass, systemic inflammation, and poor therapeutic responsiveness. While brown adipose tissue (BAT) is traditionally considered a protective, energy-dissipating organ, its...

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Detalhes bibliográficos

Principais autores:	Claudia Di Biagio, Flavia Tortolici, Francesco Gaudioso, Andrea Ninni, Francesca Giurdanella Annina, Chiara De Ranieri, Fabio Zaccaria, Francesca Sciarretta, Verteramo Luca, Francesca Arciprete, Simone Carotti, Antoine AF de Vries, Sander Kooijman, Francesca Pacello, Andrea Battistoni, Daniele Lettieri-Barbato, Katia Aquilano
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-05-01
coleção:	Cell Death and Disease
Acesso em linha:	https://doi.org/10.1038/s41419-026-08806-x
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