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LmCen −/− based vaccine is protective against canine visceral leishmaniasis following three natural exposures in Tunisia

Abstract Dogs are the main reservoir host of Leishmania infantum, etiological agent of zoonotic visceral leishmaniasis (ZVL). An effective vaccine against Canine Visceral Leishmaniasis (CVL) will help the control and elimination of ZVL. In this study, we evaluated in dogs the safety, immunogenicity,...

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Principais autores: Thouraya Boussoffara, Imen Labidi, Malek Trimèche, Ifhem Chelbi, Khalil Dachraoui, Nourhane Msallem, Mohammed Abdo Saghir Abbas, Saifedine Cherni, Kamaleshwar P. Singh, Swarnendu Kaviraj, Ranadhir Dey, Sanjay Varikuti, Sreenivas Gannavaram, Lais da S. Pereira, Wen-Wei Zhang, Patrick Lypaczewski, Shinjiro Hamano, Hirotomo Kato, Sanjay Singh, Hechmi Louzir, Hira L. Nakhasi, Abhay R. Satoskar, Greg Matlashewski, Elyes Zhioua
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2025-02-01
סדרה:npj Vaccines
גישה מקוונת:https://doi.org/10.1038/s41541-025-01070-8
תגים: הוספת תג
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