Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling

Abstract Osteoarthritis (OA) is the most prevalent joint disorder with increasing worldwide incidence. Mechanistic insights into OA pathophysiology are evolving and there are currently no disease-modifying OA drugs. An increase in protease activity is linked to progressive degradation of the cartila...

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Detalhes bibliográficos

Principais autores:	Arundhasa Chandrabalan, Andrew Firth, Robert B. Litchfield, C. Thomas Appleton, Alan Getgood, Rithwik Ramachandran
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-01-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-023-28068-3
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