Tumor cell-induced platelet aggregation accelerates hematogenous metastasis of malignant melanoma by triggering macrophage recruitment

Abstract Background Tumor cell-induced platelet aggregation (TCIPA) is not only a recognized mechanism for paraneoplastic thrombocytosis but also a potential breakthrough alternative for a low response to immune checkpoint inhibitors (ICIs) in hematogenous metastasis of malignant melanoma (MM). Howe...

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Bibliographic Details

Main Authors:	Yuyi Chen, Jie Zhou, Zishen Liu, Tongtong Wu, Shumeng Li, Yutong Zhang, Xiaohui Yin, Guowang Yang, Ganlin Zhang
Format:	Artigo
Language:	Inglês
Published:	BMC 2023-10-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	Tumor cell-induced platelet aggregation (TCIPA) Malignant melanoma (MM) Hematogenous metastasis Tumor-associated macrophage (TAM)
Online Access:	https://doi.org/10.1186/s13046-023-02856-1
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