Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C

PCSK9 is implicated in familial hypercholesterolemia via targeting the cell surface PCSK9-LDLR complex toward lysosomal degradation. The M2 repeat in the PCSK9’s C-terminal domain is essential for its extracellular function, potentially through its interaction with an unidentified “protein X”. The M...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Sepideh Mikaeeli, Ali Ben Djoudi Ouadda, Alexandra Evagelidis, Rachid Essalmani, Oscar Henrique Pereira Ramos, Carole Fruchart-Gaillard, Nabil G. Seidah
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-05-01
Schriftenreihe:	Cells
Schlagworte:	PCSK9 LDLR HFE HLA-C MHC-I lipid metabolism
Online-Zugang:	https://www.mdpi.com/2073-4409/13/10/857
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!