CD28 costimulation regulates genome-wide effects on alternative splicing.

CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone. Alternate splicing of genes adds diversity to the proteome and contributes to tissue-specific...

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Bibliografski detalji

Glavni autori:	Manish J Butte, Sun Jung Lee, Jonathan Jesneck, Mary E Keir, W Nicholas Haining, Arlene H Sharpe
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2012-01-01
Serija:	PLoS ONE
Online pristup:	http://europepmc.org/articles/PMC3386953?pdf=render
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