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Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats

Background: Cocaine addiction is a major public health problem. Despite decades of intense research, no effective treatments are available. Both preclinical and clinical studies strongly suggest that deep brain stimulation of the nucleus accumbens (NAcc) is a viable target for the treatment of cocai...

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Principais autores: Marsida Kallupi, Jenni Kononoff, Philippe A. Melas, Johanna S. Qvist, Giordano de Guglielmo, Eric R. Kandel, Olivier George
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-01-01
coleção:Brain Stimulation
Assuntos:
High-frequency stimulation
Cocaine addiction
Neuromodulation
Glutamate
Amygdala
Withdrawal
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1935861X21008019
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