Computational analysis of the structural and functional impact of the deleterious nsSNPs in the human F2R gene and their implications in glioma

The protease-activated receptor 1 (PAR1) protein, derived from the F2R gene, is integral to various physiological and pathological mechanisms and has been recognized as an oncogene in multiple studies, playing a crucial role in the aggressive and metastatic characteristics of cancer. However, no com...

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Detalhes bibliográficos

Principais autores:	Saif Mukramoon Arosh, Md. Raiyan Hosen, Md. Ismail Hosen, Atiqur Rahman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-03-01
coleção:	Biochemistry and Biophysics Reports
Assuntos:	F2R gene Proteinase-activated receptor-1 (PAR1) Non-synonymous single nucleotide polymorphism (nsSNP) Non-coding single nucleotide polymorphism (ncSNP) Missense mutation MD (molecular dynamics) simulation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405580825005175
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