Catalytic undirected methylation of unactivated C(sp3)−H bonds suitable for complex molecules
Abstract In pharmaceutical discovery, the “magic methyl” effect describes a substantial improvement in the pharmacological properties of a drug candidate with the incorporation of methyl groups. Therefore, to expedite the synthesis of methylated drug analogs, late-stage, undirected methylations of C...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2024-09-01
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| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-024-52245-1 |
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