Induction of circulating ABCB1 transcripts under platinum-based chemotherapy indicates poor prognosis and a bone micrometastatic phenotype in ovarian cancer patients

Abstract The drug efflux transporter P-glycoprotein, encoded by the ABCB1 gene, promotes acquired chemoresistance. We explored the presence and clinical relevance of circulating cell-free ABCB1 transcripts (cfABCB1tx) in ovarian cancer patients (173 longitudinal serum samples from 79 cancer patients...

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Bibliografski detalji

Glavni autori:	Franziska Maria Schwarz, Jan Dominik Kuhlmann, Jorrin Kämpfer, Anna Klimova, Daniel Martin Klotz, Lisa Freitag, Pia Herrmann, Viktoria Zinnow, Janice Smith, Theresia Scheller, Wolfgang Walther, Pauline Wimberger, Ulrike Stein
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-08-01
Serija:	Molecular Cancer
Teme:	Ovarian cancer ABCB1 Liquid biopsy Platinum-resistance
Online pristup:	https://doi.org/10.1186/s12943-024-02087-8
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