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A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus

The yellow fever virus (YFV) is a life-threatening human pathogen. Owing to the lack of available therapeutics, non-vaccinated individuals are at risk. Here, we isolated eight human monoclonal antibodies that neutralize YFV infection. Five recognized overlapping epitopes and exhibited potent neutral...

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Principais autores: Yan Li, Zhihai Chen, Lili Wu, Lianpan Dai, Jianxun Qi, Yan Chai, Shihua Li, Qihui Wang, Zhou Tong, Sufang Ma, Xiaomin Duan, Shuning Ren, Rui Song, Mifang Liang, Wenjun Liu, Jinghua Yan, George F. Gao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-11-01
coleção:The Innovation
Assuntos:
yellow fever virus
human monoclonal antibody
neutralizing antibody
prM-binding site
supersite
complex structure
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2666675822001199
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