Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice

ABSTRACT Aims/Introduction We previously showed that glucokinase haploinsufficiency improves the glucose tolerance of db/db mice by preserving pancreatic β‐cell mass and function. In the present study, we aimed to determine the effects of glucokinase haploinsufficiency on the β‐cell mass and functio...

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Bibliografische Detailangaben

Hauptverfasser:	Ikumi Shigesawa, Akinobu Nakamura, Yuki Yamauchi, Shinichiro Kawata, Asuka Miyazaki, Hiroshi Nomoto, Hiraku Kameda, Yasuo Terauchi, Tatsuya Atsumi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2024-12-01
Schriftenreihe:	Journal of Diabetes Investigation
Schlagworte:	β‐cell mass Glucokinase Glucose‐stimulated insulin secretion
Online-Zugang:	https://doi.org/10.1111/jdi.14307
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