A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance in rheumatoid arthritis by targeting on Syk induced mTOR and PKCθ imbalance

IntroductionDysfunctional self-tolerance is thought to play a crucial role in the onset of rheumatoid arthritis (RA) pathogenesis. Poorly functioning regulatory T cells (Tregs) lead to extreme situations where self-tolerance is robustly disrupted. However, there are many uncertainties regarding its...

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Auteurs principaux:	Ping Li, Xin Yin, Xinzhu Wen, Xuyu Li, Yuqing Wang, Hongyan Zhan, Hanqing Che, Chunsuo Yao, Qi Hou, Ziqian Zhang, Ruifang Zheng, Mingbao Lin
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2025-05-01
Collection:	Frontiers in Immunology
Sujets:	EIE-2 rheumatoid arthritis Treg-dependent tolerance Syk PKCθ/mTOR
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524491/full
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