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Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA

µ-Conotoxin PIIIA, in the sub-picomolar, range inhibits the archetypal bacterial sodium channel NaChBac (NavBh) in a voltage- and use-dependent manner. Peptide µ-conotoxins were first recognized as potent components of the venoms of fish-hunting cone snails that selectively inhibit voltage...

Täydet tiedot

Tallennettuna:
Päätekijät: Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Vyacheslav S. Korkosh, Sun Huang, Denis McMaster, Robert Glavica, Denis B. Tikhonov, Boris S. Zhorov, Robert J. French
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2019-08-01
Sarja:Marine Drugs
Aiheet:
µ-conotoxin PIIIA
voltage-gated sodium channels
bacterial sodium channels, prokaryotic sodium channels (NavBacs)
eukaryotic sodium channels (Nav1s)
voltage- and use-dependent block
Linkit:https://www.mdpi.com/1660-3397/17/9/510
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