Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids

H9N2 is currently the second most common avian influenza A virus subtype infecting humans. Monitoring viral phenotypic and genotypic adaptation to humans is crucial for risk assessment. Here, we compared the replication of an H9N2 human isolate collected in 2024 (A/HK/2346/2024) to a human isolate c...

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Autors principals:	Lin-Lei Chen, Jonathan Daniel Ip, Wan-Mui Chan, Stephanie Joy-Ann Lam, Rhoda Cheuk-Ying Leung, Cyril Chik-Yan Yip, Xiaojuan Zhang, Allen Wing-Ho Chu, Hoi-Wah Tsoi, Aixin Li, Kwok-Hung Chan, Carol Ho-Yan Fong, Lei Wen, Jane Hau-Ching Poon, Janice Yee-Chi Lo, Kristine Shik Luk, Jasper Fuk-Woo Chan, Honglin Chen, Jie Zhou, Kwok-Yung Yuen, Mike Yat-Wah Kwan, Kelvin Kai-Wang To
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2025-12-01
Col·lecció:	Emerging Microbes and Infections
Matèries:	Avian influenza H9N2 human organoids intrahost evolution human adaptive amino acid substitutions
Accés en línia:	https://www.tandfonline.com/doi/10.1080/22221751.2025.2576574
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