Perampanel increases seizure threshold in pentylenetetrazole-kindled mice and improves behavioral dysfunctions by modifying mRNA expression levels of BDNF/TrkB and inflammatory markers

Perampanel (PER), a novel 3rd-generation antiseizure drug that modulates altered post-synaptic glutamatergic storming by selectively inhibiting AMPA receptors, is recently approved to treat intractable forms of seizures. However, to date, presumably consequences of long-term PER therapy on the comor...

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Detalhes bibliográficos

Principais autores:	Nadia Perveen, Faleh Alqahtani, Waseem Ashraf, Muhammad Fawad Rasool, Syed Muhammad Muneeb Anjum, Iram Kaukab, Tanveer Ahmad, Saleh A. Alqarni, Imran Imran
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2024-01-01
coleção:	Saudi Pharmaceutical Journal
Assuntos:	Perampanel Epilepsy vEEG PTZ Oxidative stress RT-PCR
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1319016423004255
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