Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade

Female sex and history of prior pregnancies are associated with favorable melanoma outcomes. Here, we show that much of the melanoma protective effect likely results from estrogen signaling through the G protein-coupled estrogen receptor (GPER) on melanocytes. Selective GPER activation in primary me...

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Bibliografische gegevens

Hoofdauteurs:	Christopher A Natale, Jinyang Li, Junqian Zhang, Ankit Dahal, Tzvete Dentchev, Ben Z Stanger, Todd W Ridky
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	eLife Sciences Publications Ltd 2018-01-01
Reeks:	eLife
Onderwerpen:	GPER GPCR melanoma
Online toegang:	https://elifesciences.org/articles/31770
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