Case Report: CAR-T therapy for relapsed diffuse large B-cell lymphoma in a patient with pre-existing Parkinson’s disease—unfolding clinical challenges

Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the outcomes for relapsed/refractory diffuse large B-cell lymphoma (DLBCL). However, immune effector cell–associated neurotoxicity syndrome (ICANS) remains a concern. Pre-existing neurological disorders such as Parkinson’s disease (PD)...

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Hlavní autoři:	Anas Ibraheem, Helena Vincentelli, Andrea Kuhnl, Emil A Kumar, Andres Moya Davila, Piers EM Patten, Deborah Yallop, Reuben Benjamin, Charlotte Graham, Aaron Niblock, Robin Sanderson
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-02-01
Edice:	Frontiers in Oncology
Témata:	CAR-T therapy diffuse large B-cell lymphoma (DLBCL) immune effector cell–associated neurotoxicity syndrome (ICANS) multidisciplinary approach parkinsonism Parkinson’s disease (PD)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1759390/full
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