<i>GBA</i> Variants and Parkinson Disease: Mechanisms and Treatments

The <i>GBA</i> gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which maintains glycosphingolipid homeostasis. Approximately 5–15% of PD patients have mutations in the <i>GBA</i> gene, making it numerically the most important genetic risk factor for Parkinson disease (PD). Clinicall...

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書目詳細資料

Principais autores:	Laura Smith, Anthony H. V. Schapira
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2022-04-01
叢編:	Cells
主題:	Parkinson disease <i>GBA</i> alpha-synuclein autophagy unfolded protein response lipids
在線閱讀:	https://www.mdpi.com/2073-4409/11/8/1261
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